Principal / Senior Scientist Cell Biology

Job Description ABOUT THE COMPANYYellowstone Biosciences is a biotechnology spinout company located in Oxford, whose goal is to pioneer new cancer treatments using advanced T-cell therapies based on groundbreaking research from the MRC Weatherall Institute of Molecular Medicine at the University of Oxford.ABOUT THE ROLEWe are seeking a highly motivated and detail-oriented Principal Scientist to join our Cell Biology Team. The successful candidate will help drive experimental strategy, oversee the design and execution of in vitro studies, and play a key role in mentoring and training junior scientists. This position offers an exciting opportunity to shape the scientific direction of a growing company and to contribute directly to its research and development strategy.RESPONSIBILITIESLead the planning, execution, and interpretation of cell biology experiments to support discovery and preclinical programs.Supervise and train research associates and scientists, fostering a culture of scientific rigor, collaboration, and professional growth.Develop, implement, and optimize assays including flow cytometry, ELISA, Western blotting, and advanced cell culture models.Guide molecular biology studies (e.g., gene expression analysis, cloning, transfection, CRISPR) to support mechanistic investigations.Ensure high-quality data generation, documentation, and communication across multidisciplinary teams.Collaborate with project leads to design experimental plans, review data, and integrate findings into project decisions.Lead presentations at internal meetings and contribute to scientific reports and regulatory documentation.Contribute to the shaping of the companys scientific strategy and research roadmap.QUALIFICATIONSPhD (or equivalent experience) in Cell Biology, Molecular Biology, Immunology, or related scientific field.Proven experience (typically 5+ years post-PhD) in cell biology or related research within a biotech/biopharma settings.REQUIRED SKILLSStrong technical background in cell culture, flow cytometry, ELISA, Western blotting, and molecular biology techniques.Familiarity with a range of cell and molecular biology techniques including T cell assays, killing assays, cytokine assays, designing and executing recombinant DNA sub-cloning strategies, making lentiviral supernatants, lentiviral transduction, complex co-culture or 3D culture assays.Experience leading projects, overseeing the experimental strategy and co-ordinating the work of other team members.Excellent communication and organizational skills, with the ability to present data clearly and influence across functional teams.Demonstrated ability to work proactively in a dynamic, fast-evolving start-up environment.PREFERRED SKILLS(Desired but not essential) Direct hands-on laboratory experience in testing and developing of biologics including the assessment of the biological impact of their engagement with therapeutic targets.Ability to independently lead programmes to advance the companys goals, review competing priorities and recommend strategies to advance the programme.Inclusive, collaborative, and thrives in a team environment with a flexible approach to working.Demonstrable problem-solving ability, creative thinking and be pro-active in driving the project forwards.(Desired but not essential) Experience in the design and oversight of in vivo experiments.Passionate about scientific innovation and advancing new therapeutic approaches.PAY RANGE AND COMPENSATION PACKAGECompetitive salary and career development opportunities.If youre excited to grow your skills and make a real impact in cutting-edge cell biology research, wed love to hear from you.

Created: 2026-03-20