Medicinal Chemist

Job Summary/Experience:Genome Therapeutics Ltd (GTx) is seeking a medicinal chemist with experience in pre-clinical drug discovery to drive the development of novel therapeutics that target G-quadruplex structures. The ideal candidate will manage outsourced drug discovery activities and play a key role in the design and synthesis of lead compounds, applying a comprehensive understanding of medicinal chemistry principles across internal programmes from hit-to-lead through to candidate nomination.GTx is a fast paced multidisciplinary company, offering training and experience in genomics, computational biology, drug discovery and clinical studies.Location: This is an on-site position based at the GTx labs in Cambridge UK.  Key Responsibilities Leverage expertise in organic and medicinal chemistry to design and synthesise novel small molecules across multiple programmes and chemotypesMonitor and interpret biological, ADME/PK, and physicochemical property data to propose and execute innovative strategies for improving key drug attributes Manage multiple CRO relationships, providing synthetic and medicinal chemistry expertise and guidance, and driving productivity and deliverablesProvide regular updates on project results both internally and externallyEffective written communication, including responsibility for drafting and maintaining patent applications and scientific publicationsMeticulous record-keeping and strong data organisation using commercial data management systems and electronic notebooks Essential Skills/Experience:PhD in synthetic organic chemistry with >5 years industry experience within pharma/biotech Exposure to medicinal chemistry programmes from hit identification through to candidate nominationUnderstanding of the multi-parameter optimisation process and ability to integrate disease biology, ADME/PK and toxicology data to solve complex drug discovery problems.Management of outsourced drug discovery projects Desirable Skills/Experience:Prior experience of drug discovery programmes in the field of oncologyKnowledge of in silico tools to aid drug design

Created: 2025-09-10